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描述 产品目录编号 14-547M 品牌系列 Upstate
商名 - Upstate
描述 CaM Kinase IV Protein, active, 250 µg 概述 C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV 应用 应用 Active, C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_001744.3
Entrez基因汇总 The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. 基因符号 - CaMK-GR
- CAMK4
- MGC36771
蛋白靶 CaMKIV 纯化方法 Ni2+/NTA-agarose 靶子系列 CAMK UniProt编号 - Q16566
UniProt汇总 FUNCTION: SwissProt: Q16566 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory (By similarity).
SIZE: 473 amino acids; 51926 Da
SUBUNIT: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial ovarian cancer tissue.
PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
SIMILARITY: SwissProt: Q16566 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-547) and in bulk (cat# 14-547-K).
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