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merck millipore,默克密理博,23-028M,IkBa Protein, activated, 250 µg
产品名称：IkBa Protein, activated, 250 µg
产品型号：23-028M
Activated, full length, recombinant human IκBα. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using IKKα, active. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
merck millipore,默克密理博,23-028M,IkBa Protein, activated, 250 µg
- 产品介绍
重要规格表
主要应用 品种 级联部件 EA Human Substrate 描述 产品目录编号 23-028M 品牌系列 Upstate
商名 - Upstate
描述 IkBa Protein, activated, 250 µg 长描述 N-terminal c-Myc, 6His-tagged, recombinant human IκBα full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. Phosphorylated in vitro using IKKα, active (Item # 14-461) Alternate Names - Major histocompatibility complex enhancer-binding protein MAD3
- NF-kappa-B inhibitor alpha
- I-kappa-B-alpha
背景信息 IκBα is a cellular protein that inhibits the transcription factor NF-κB. NF-κB plays a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens. In non-stimulated cells NF-κB is sequestered in the cytoplasm via the inhibitory protein IκBα, which obscures the nuclear localization signal of NF-κB and also blocks its ability to bind DNA. In response to various stimuli, including viral infection, ultraviolet radiation and inflammatory cytokines, IκBα is phosphorylated by the protein kinase complex IKK, which triggers its rapid degradation by ubiquitin mediated proteolysis. The liberated NF-κB then translocates to the nucleus and activates the expression of target genes. Mutations in the gene for IκBα result in the functional impairment of NF-κB which causes a decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection. 应用 应用 Activated, full length, recombinant human IκBα. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using IKKα, active. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays. 主要应用 - Enzyme Assay
生物信息 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. 级联部件 Substrate Entrez基因编号 - M69043 (GenBank Number)
纯化方法 Purified using immobilized metal affinity chromatography. 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 250 µg
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