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merck millipore,默克密理博,219677,CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
产品名称：CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
产品型号：219677
The CFTR Inhibitor IV, PPQ-102, also referenced under CAS 931706-15-9, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,219677,CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₆H₂₂N₄O₃ 931706-15-9 描述 概述 A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 µM PPQ-102). PPQ-102 at 5 µM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture. 产品目录编号 219677 品牌系列 Calbiochem®
同义词 7,9-Dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido-[4ʹ,5ʹ-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV 参考 参考 Tradtrantip, L., et al. 2009. J. Med. Chem. 52, 6447. 产品信息 CAS号 931706-15-9 形式 White crystalline solid Hill配方 C₂₆H₂₂N₄O₃ 化学配方 C₂₆H₂₂N₄O₃ Molar Mass 438.5 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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