merck millipore,默克密理博,219672,CFTR Inhibitor III, OXO-172

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Merck Millipore 默克密理愽

merck millipore,默克密理博,219672,CFTR Inhibitor III, OXO-172 - Calbiochem

经验配方
C₁₈H₁₀F₃NO₄S

描述
概述	A cell-permeable CFTR_inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR_inh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR_inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC₅₀ = 1.4 µM vs. 0.38 µM with CFTR_inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
产品目录编号	219672
品牌系列	Calbiochem®
同义词	3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172

参考
参考	Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.

生物信息
纯度	≥95% by HPLC and NMR

理化信息
溶解度	DMSO or EtOH

安全信息
R相	R: 36/37/38-43 Irritating to eyes, respiratory system and skin. May cause sensitization by skin contact.
S相	S: 26-36/37-45-61 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/safety data sheet.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,219672,CFTR Inhibitor III, OXO-172 - Calbiochem

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