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经验配方 C₂₅H₁₉NO₃ 描述 概述 A cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight. 产品目录编号 219556 品牌系列 Calbiochem®
同义词 Ceranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III 参考 参考 Draper, J., et al. 2011, Mol. Cancer Ther. 10, 2052. 产品信息 形式 White powder Hill配方 C₂₅H₁₉NO₃ 化学配方 C₂₅H₁₉NO₃ Molar Mass 381.42 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,407129,D-myo-Inositol 1,4,5-Trisphosphate, 3-Deoxy-3-fluoro-, Hexasodium Salt - CAS 129365-68-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,17-10085,Magna ChIP™ A/G Chromatin Immunoprecipitation Kit
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