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merck millipore,默克密理博,219492,Cdk4/6 Inhibitor IV - CAS 359886-84-3 - Calbiochem
产品名称：Cdk4/6 Inhibitor IV - CAS 359886-84-3 - Calbiochem
产品型号：219492
The Cdk4/6 Inhibitor IV, also referenced under CAS 359886-84-3, controls the biological activity of Cdk4/6. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>
merck millipore,默克密理博,219492,Cdk4/6 Inhibitor IV - CAS 359886-84-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₇H₃₂N₆O 359886-84-3 描述 概述 A cell-permeable triaminopyrimidine compound that acts as a reversible and ATP-competitive inhibitor against Cyclin D1-complexed, but not Cyclin D2-complexed, Cdk4 and Cdk6 (IC50 = 1.5 and 5.6 µM, respectively) with much reduced activity against Cdk5/p35 (IC50 = 25 µM) and little or no activity towards Cdk1/CycB, Cdk2/CycA, Cdk2/CycE, v-abl, c-met, IGF-1R, or IR (IC50 >10 µM). CINK4 (at 5 and 10 µM) effectively inhibits cellular Cdk4 substrate pRb phosphorylation and prevents serum-stimulated G1/S transition of serum starved pRb-positive, but not pRb-negative, cultures. CINK4 is shown to exert a ~46% suppression of human colon carcinoma HCT116-derived tumor growth in mice in vivo (30 mg/kg; twice a day, i.p.). 产品目录编号 219492 品牌系列 Calbiochem®
同义词 trans-4-((6-(ethylamino)-2-((1-(phenylmethyl)-1H-indol-5-yl)amino)-4-pyrimidinyl)amino)-cyclohexanol, CINK4 参考 参考 Soni, R., et al. 2001. J. Natl. Cancer Inst. 93, 436. 产品信息 CAS号 359886-84-3 形式 Pale amber solid Hill配方 C₂₇H₃₂N₆O 化学配方 C₂₇H₃₂N₆O Molar Mass 456.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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