merck millipore,默克密理博,219491,Cdk/Crk Inhibitor - CAS 784211-09-2

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Merck Millipore 默克密理愽

merck millipore,默克密理博,219491,Cdk/Crk Inhibitor - CAS 784211-09-2 - Calbiochem

经验配方	CAS号
C₂₃H₂₂Cl₂N₄O₃	784211-09-2

描述
概述	A cell-permeable pyrazolo-pyrimidinone compound that acts as a potent, selective, and ATP-competitive inhibitor of Cdks (IC₅₀ = 48 nM, 15 nM, 9 nM, 10 nM, 71 nM, and 9 nM for Cdk1/B, Cdk2/E, Cdk3/E, Cdk5/p35, Cdk7/H/MAT1, and Cdk9, respectively). It inhibits Cdk4/D1, Cdk6/D3, and GSK-3β only at much higher concentrations (IC₅₀ = 839 nM, 282 nM, and 754 nM, respectively) and exhibits little activity towards a panel of 60 other kinases. A broad-spectrum growth inhibitor toward tumor cells, but not non-transformed quiescent fibroblasts.
产品目录编号	219491
品牌系列	Calbiochem®
同义词	1-(2,6-Dichlorophenyl)-1,5-dihydro-6-((4-(2-hydroxyethoxy)phenyl)methyl)-3-(1-methylethyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one, RGB-286147, Cdk7 Inhibitor IV

参考
参考	Caligiuri, M., et al. 2005. Chem. Biol. 12, 1103.

生物信息
主靶	Cdk1/B, Cdk2/E, Cdk3/E, Cdk5/p35, Cdk7/H/MAT1, and Cdk9
主靶IC₅₀	48 nM, 15 nM, 9 nM, 10 nM, 71 nM, and 9 nM for Cdk1/B, Cdk2/E, Cdk3/E, Cdk5/p35, Cdk7/H/MAT1, and Cdk9, respectively
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,219491,Cdk/Crk Inhibitor - CAS 784211-09-2 - Calbiochem

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