merck millipore,默克密理博,219381,Cathepsin K Inhibitor III

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Merck Millipore 默克密理愽

merck millipore,默克密理博,219381,Cathepsin K Inhibitor III - Calbiochem

经验配方
C₃₀H₄₃N₇O₆

描述
概述	A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
产品目录编号	219381
品牌系列	Calbiochem®
同义词	Inhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂

参考
参考	Wang, D., et al. 2002. Biochemistry 41, 8849.

产品信息
具有ATP竞争性	N
形式	Lyophilized white solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₃₀H₄₃N₇O₆
化学配方	C₃₀H₄₃N₇O₆
Molar Mass	597.7
吸湿	Hygroscopic
肽序列	H-Phe-Leu-NHNH-CO-NHNH-Leu-Z
可逆	Y

储存和货运信息
货运代码	Blue Ice Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,219381,Cathepsin K Inhibitor III - Calbiochem

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