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merck millipore,默克密理博,215900,Carbonic Anhydrase IX/XII Inhibitor - Calbiochem
产品名称：Carbonic Anhydrase IX/XII Inhibitor - Calbiochem
产品型号：215900
The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,215900,Carbonic Anhydrase IX/XII Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₃H₁₂N₄O₅S 描述 概述 A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg. 产品目录编号 215900 品牌系列 Calbiochem®
同义词 CAIX Inhibitor 参考 参考 Pacchiano, F., et al. 2011. J Med Chem. 54, 1896. 产品信息 形式 White solid Hill配方 C₁₃H₁₂N₄O₅S 化学配方 C₁₃H₁₂N₄O₅S Molar Mass 336.3 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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