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描述 概述 Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.W. of 93 kDa (α), 75 kDa (β), and 32 kDa (γ) linked by disulfide bonds. Present in normal human serum at 400 µg/ml. On activation of complement via the classical pathway, the C1s subcomponent of the C1 complex is converted to an active serine protease that cleaves the C4 α-chain at peptide bond 77, resulting in production of C4a (M.W. 8740) and C4b fragments (M.W. 193 kDa). The released C4a peptide is one of the three complement-derived anaphylatoxins. The nascent C4b fragment can form a covalent ester bond with target surfaces. This covalent attachment of C4b to target acceptors is required for continuation of activation via classical pathway. 产品目录编号 204886 品牌系列 Calbiochem®
参考 参考 Janatova, J. 1983. Ann. N.Y. Acad. Sci. 421, 218.
Hammer, C.H., et al. 1981. J. Biol. Chem. 256, 3995.产品信息 CAS号 80295-48-3 形式 Liquid 配方 In PBS, pH 7.2. Molar Mass 200000 生物信息 生物活性 ≥60% of the C4 activity present in freshly drawn normal human serum on a mg to mg basis 纯度 ≥90% by SDS-PAGE 来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. 特异活性 >3X10⁵ C4H50 units/mg 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
上一件merck millipore产品：merck millipore,默克密理博,679100,Vitamin D₂, 1α-Hydroxy- - CAS 54573-75-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,2100-OP,OmniPur 6X Loading Buffer, 15% Ficoll - Calbiochem
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