merck millipore,默克密理愽
  • merck millipore,默克密理博,203987,Butein - CAS 487-52-5 - Calbiochem

  • merck millipore,默克密理博,203987,Butein - CAS 487-52-5 - Calbiochem

    产品名称：Butein - CAS 487-52-5 - Calbiochem
    产品型号：203987
    A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor.

    merck millipore,默克密理博,203987,Butein - CAS 487-52-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,203987,Butein - CAS 487-52-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂O₅487-52-5
    描述
    概述 A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
    产品目录编号 203987
    品牌系列 Calbiochem®
    同义词 2ʹ,4ʹ,3,4-Tetrahydroxychalcone
    参考
    参考 Howitz, K.T., et al. 2003. Nature 425, 191.
    Chan, S.C., et al. 1998. Planta Med. 64, 153.
    Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
    Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
    Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
    产品信息
    CAS号 487-52-5
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₅H₁₂O₅
    化学配方 C₁₅H₁₂O₅
    Molar Mass 272.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Tyrosine kinase activity of the EGF receptor
    主靶IC50 65 µM against tyrosine kinase activity of the EGF receptor
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,203987,Butein - CAS 487-52-5 - Calbiochem

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