merck millipore,默克密理愽
  • merck millipore,默克密理博,14-429,MEK1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-429,MEK1 Protein, active, 10 µg

    产品名称：MEK1 Protein, active, 10 µg
    产品型号：14-429
    Active, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.

    merck millipore,默克密理博,14-429,MEK1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-429,MEK1 Protein, active, 10 µg

    描述
    产品目录编号 14-429
    品牌系列 Upstate
    商名
    • Upstate
    描述 MEK1 Protein, active, 10 µg
    概述 N-terminal GST and Cterminal His6-tagged, recombinant full-length human MEK1
    应用
    应用 Active, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002755.2
    Entrez基因汇总 The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
    基因符号
    • MKK1
    • MAP2K1
    • MAPKK1
    • PRKMK1
    • MEK1
    蛋白靶 MEK1
    纯化方法 Purified using glutathione agarose followed by Ni2+/NTA agarose, activated using c-Raf and the re-purified using Ni2+/NTA agarose
    靶子系列 STE
    UniProt编号
    • Q02750
    UniProt汇总 FUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
    SIZE: 393 amino acids; 43439 Da
    SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.
    PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
    DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
    SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of MBP
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250μg size as catalog # 14-429M - Call for pricing and availability.

    merck millipore,默克密理博,14-429,MEK1 Protein, active, 10 µg

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下一件merck millipore产品：merck millipore,默克密理博,17-10082,PureEpi™ Chromatin Preparation and Optimization Kit


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