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merck millipore,默克密理博,196876,BAY 41-2272 - CAS 256376-24-6 - Calbiochem
产品名称：BAY 41-2272 - CAS 256376-24-6 - Calbiochem
产品型号：196876
A cell-permeable pyrazolopyridinylpyrimidine compound that acts as a selective and potent stimulator of soluble guanylate cyclase (effective dose ~ 0.1 nM to 100 µM using recombinant soluble guanylate More>>
merck millipore,默克密理博,196876,BAY 41-2272 - CAS 256376-24-6 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₀H₁₇FN₆ 256376-24-6 描述 概述 A cell-permeable pyrazolopyridinylpyrimidine compound that acts as a selective and potent stimulator of soluble guanylate cyclase (effective dose ~ 0.1 nM to 100 µM using recombinant soluble guanylate cyclase). The mode of activation is NO-independent and appears to be mediated through direct binding to the α1 and α2 subunits. Shown to be effective in treating numerous cardiovascular conditions in animal models. Inhibits phenylephrine-induced constriction of rabbit aortic rings (IC50 = 304 nM) and blocks collagen-induced aggregation of human platelets (IC50 = 36 nM). Does not inhibit phosphodiesterases. 产品目录编号 196876 品牌系列 Calbiochem®
同义词 5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine 参考 参考 Boerrigter, G., et al. 2003. Circulation 107, 686.
Kalsi, J.S., et al. 2003. J Urol. 169, 761.
Koglin, M., et al. 2002. Biochem. Biophys. Res. Commun. 292, 1057.
Becker, E.M., et al. 2001. BMC Pharmacol. 1, 13.
Stasch, J.P., et al. 2001. Nature 410, 212.产品信息 CAS号 256376-24-6 具有ATP竞争性 N 形式 White solid Hill配方 C₂₀H₁₇FN₆ 化学配方 C₂₀H₁₇FN₆ Molar Mass 360.4 可逆 N 结构配方图像 生物信息 主靶 Soluble guanylate cyclase 主靶IC50 304 nM inhibiting phenylephrine-induced constriction of rabbit aortic rings; 36 nM in blocking collagen-induced aggregation of human platelets 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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