merck millipore,默克密理博,196440,Batimastat - CAS 130370-60-4

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merck millipore,默克密理博,196440,Batimastat - CAS 130370-60-4 - Calbiochem
产品名称：Batimastat - CAS 130370-60-4 - Calbiochem
产品型号：196440
Batimastat primarily used in Inhibition.

merck millipore,默克密理博,196440,Batimastat - CAS 130370-60-4 - Calbiochem

产品介绍

merck millipore,默克密理博,196440,Batimastat - CAS 130370-60-4 - Calbiochem

重要规格表

经验配方	CAS号
C₂₃H₃₁N₃O₄S₂	130370-60-4

描述
概述	A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC₅₀ = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn²⁺, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC₅₀ = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).
产品目录编号	196440
品牌系列	Calbiochem®
同义词	(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94

参考
参考	Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210. Whittaker, M., et al. 1999. Chem. Rev. 99, 2735. Parvathy, S., et al. 1998. Biochemistry 37, 1680. Parvathy, S., et al. 1998. FEBS Lett. 431, 63. Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209. Moss, M.L., et al. 1997. Nature 385, 733. Eccles, S.A., et al. 1996. Cancer Res. 56, 2815. Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293. Wang, X., et al. 1994. Cancer Res. 54, 4726. Davies, B., et al. 1993. Cancer Res. 53, 2087.

参考

Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.

产品信息
CAS号	130370-60-4
形式	Off-white solid
Hill配方	C₂₃H₃₁N₃O₄S₂
化学配方	C₂₃H₃₁N₃O₄S₂
Molar Mass	477.6
结构配方图像

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.