merck millipore,默克密理愽
  • merck millipore,默克密理博,171261,InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

  • merck millipore,默克密理博,171261,InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

    产品名称：InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
    产品型号：171261
    The InSolution™ AMPK Inhibitor, Compound C, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Depho More>>

    merck millipore,默克密理博,171261,InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,171261,InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₅N₅O866405-64-3
    描述
    概述 A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
    产品目录编号 171261
    品牌系列 Calbiochem®
    同义词 Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
    参考
    参考 Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
    Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
    Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
    Inoki, K., et al. 2003. Cell 115, 577.
    Fryer, L.G., 2002. FEBS Lett. 531, 189.
    Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
    产品信息
    CAS号 866405-64-3
    具有ATP竞争性 Y
    形式 Liquid
    配方 Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
    Hill配方 C₂₄H₂₅N₅O
    化学配方 C₂₄H₂₅N₅O
    Molar Mass 399.5
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 AMPK
    主靶IC50 25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
    主靶Ki EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,171261,InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

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