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merck millipore,默克密理博,16-107,Anti-PI3 Kinase Antibody, p85 Protein, agarose conjugate, 200 µg
产品名称：Anti-PI3 Kinase Antibody, p85 Protein, agarose conjugate, 200 µg
产品型号：16-107
Anti-PI3 Kinase Antibody, p85, agarose conjugate detects level of PI3 Kinase & has been published & validated for use in IP.
merck millipore,默克密理博,16-107,Anti-PI3 Kinase Antibody, p85 Protein, agarose conjugate, 200 µg
- 产品介绍
描述 产品目录编号 16-107 品牌系列 Upstate
商名 - Upstate
描述 Anti-PI3 Kinase Antibody, p85 Protein, agarose conjugate, 200 µg 概述 Anti-PI 3-Kinase antibody (06-195) covalently coupled to protein A-agarose by dimethyl-pimelimidate. 产品信息 格式 Gel Immobilized 演示 PBS, pH 7.4, containing 0.05% sodium azide 应用 应用 Anti-PI3 Kinase Antibody, p85, agarose conjugate detects level of PI3 Kinase & has been published & validated for use in IP. 主要应用 - Immunoprecipitation
应用说明 Suitable for immunoprecipitation and affinity purification. 生物信息 宿主 Rabbit 品种反应性 HumanRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_181524.1
- NM_181504.2
- NM_181523.1
Entrez基因汇总 Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. 基因符号 - p85-ALPHA
- PIK3R1
- GRB1
- PI3K
靶子系列 PI3K/PI4K UniProt编号 - P27986
UniProt汇总 FUNCTION: SwissProt: P27986 # Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
SIZE: 724 amino acids; 83598 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits. Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3 (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C- terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1.
TISSUE SPECIFICITY: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
DOMAIN: SwissProt: P27986 The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
PTM: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.DISEASE:SwissProt: P27986 # Defects in PIK3R1 are a cause of severe insulin resistance.
SIMILARITY: Belongs to the PI3K p85 subunit family. & Contains 1 Rho-GAP domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitating PI 3-Kinase from RIPA lysate of EGF-stimulated human A431 carcinoma cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 4°C 包装信息 数量 200 µg
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下一件merck millipore产品：merck millipore,默克密理博,454854,MAP Kinase 2, His•Tag, Human, Recombinant, E. coli
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