merck millipore,默克密理博,14-912M,TGFBR-1 Protein, active, 250 µg

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

描述
产品目录编号	14-912M
品牌系列	Upstate
商名	Upstate
描述	TGFBR-1 Protein, active, 250 µg
概述	N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.
Alternate Names	ALK-5 Activin receptor-like kinase 5 SKR4 Serine/threonine-protein kinase receptor R4 TGF-beta type I receptor TbetaR-I TGF-beta receptor type I Transforming growth factor-beta receptor type I TGFR-1 TGF-beta receptor type-1
背景信息	Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS).

产品信息
演示	50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

应用
应用	Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	Expressed by baculovirus in Sf21 insect cells.
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_004612
基因符号	TGFBR1
蛋白靶	TGFBR1
纯化方法	Glutathione agarose affinity chromatography
靶子系列	TKL
UniProt编号	Q64729 (mouse) P36897

产品使用声明
质量保证	Routinely evaluated by phosphorylation of casein.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

包装信息
数量	250 µg
包装	Also available in 10 μg size (cat#14-912) and in bulk (cat# 14-912-K).

merck millipore,默克密理博,14-912M,TGFBR-1 Protein, active, 250 µg

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech