merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1525,Anti-Exportin T Antibody, clone LOS1

  • merck millipore,默克密理博,05-1525,Anti-Exportin T Antibody, clone LOS1

    产品名称：Anti-Exportin T Antibody, clone LOS1
    产品型号：05-1525
    Use Anti-Exportin T Antibody, clone LOS1 (Mouse Monoclonal Antibody) validated in WB to detect Exportin T also known as tRNA (nuclear export receptor for tRNAs).

    merck millipore,默克密理博,05-1525,Anti-Exportin T Antibody, clone LOS1

  • 产品介绍
  • merck millipore,默克密理博,05-1525,Anti-Exportin T Antibody, clone LOS1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1525
    描述 Anti-Exportin T Antibody, clone LOS1
    Alternate Names
    • tRNA exportin
    • exportin, tRNA (nuclear export receptor for tRNAs)
    背景信息 Exportin T mediates the nuclear export of tRNAs in yeast and mammals. This protein is a member of the importin/karyopherin beta superfamily. Commonly called Los1p in yeast and Xpo-t in vertebrate, Exportin T plays a direct role in tRNA export from the nucleus into the cytoplasm. Nuclear export occurs in cooperation with the small GTPase Ran (Gsp1p) making tRNA available for translation. In yeast, Los1p is not essential for viability, suggesting that alternative tRNA export pathways exist.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-Exportin T Antibody, clone LOS1 (Mouse Monoclonal Antibody) validated in WB to detect Exportin T also known as tRNA (nuclear export receptor for tRNAs).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to Chlamydomonas Exportin-T.
    表位 Unknown
    克隆 LOS1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Exportin-T.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_009166
    Entrez基因汇总 This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq]
    基因符号
    • exportin-T
    • XPOT
    • Exportin(tRNA)
    • XPO3
    纯化方法 Protein G purfied
    UniProt编号
    • O43592
    UniProt汇总 FUNCTION: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

    SUBUNIT STRUCTURE: Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

    SEQUENCE SIMILARITIES: Belongs to the exportin family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 1 µg/ml of this antibody detected Exportin-T on 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1525,Anti-Exportin T Antibody, clone LOS1

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