merck millipore,默克密理愽
  • merck millipore,默克密理博,14-779,MKP5, active

  • merck millipore,默克密理博,14-779,MKP5, active

    产品名称：MKP5, active
    产品型号：14-779


    merck millipore,默克密理博,14-779,MKP5, active

  • 产品介绍
  • merck millipore,默克密理博,14-779,MKP5, active

    描述
    产品目录编号 14-779
    商名
    • Upstate
    描述 MKP5, active
    概述 Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the
    phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily
    (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue
    distribution and subcellular localization, and different modes of inducibility of their expression by extracellular
    stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization
    is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various
    tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different
    isoforms have been found for this gene.
    产品信息
    演示 Protein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    主要应用
    • Phosphatase Assay
    生物信息
    来源 N-terminal 6His-tagged, recombinant, human MKP5, amino acids 320-end, expressed in E. coli.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_007207
    基因符号
    • MKP5
    • DUSP10
    纯化方法 Purified using Ni2+/NTA agarose.
    UniProt编号
    • Q9Y6W63
    产品使用声明
    质量保证 Routinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250μg size as catalog # 14-779M and in bulk as catalog # 14-779-K.

    merck millipore,默克密理博,14-779,MKP5, active

上一件merck millipore产品：merck millipore,默克密理博,528121,PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,317642,Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem


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