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merck millipore,默克密理博,14-729,PDGFR α (550-end,D842V) Protein, active, 10 µg
产品名称:PDGFR α (550-end,D842V) Protein, active, 10 µg
产品型号:14-729
Active, N-terminal 6His-tagged, recombinant, human PDGFR alpha amino acids 550-end, containing the D842V mutation. For use in Kinase Assays.
merck millipore,默克密理博,14-729,PDGFR α (550-end,D842V) Protein, active, 10 µg
- 产品介绍
描述 产品目录编号 14-729 品牌系列 Upstate
商名 - Upstate
描述 PDGFR α (550-end,D842V) Protein, active, 10 µg 概述 N-terminal 6His-tagged, recombinant, human PDGFR alpha amino acids 550-end, containing the D842V mutation. 应用 应用 Active, N-terminal 6His-tagged, recombinant, human PDGFR alpha amino acids 550-end, containing the D842V mutation. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_006206.3
Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. 基因符号 - CD140A
- PDGFRA
- CD140a
- PDGF-R-alpha
- MGC74795
- PDGFR2
- Rhe-PDGFRA
蛋白靶 PDGFRα 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - P16234
UniProt汇总 FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
SIZE: 1089 amino acids; 122670 Da
SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C from date of shipment 包装信息 数量 10 µg 包装 Also available in 250μg size as catalog # 14-729M - Call for pricing and availability.
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