merck millipore,默克密理愽
  • merck millipore,默克密理博,14-596M,LKB1/STRADα/MO25α Protein, active, 125 µg

  • merck millipore,默克密理博,14-596M,LKB1/STRADα/MO25α Protein, active, 125 µg

    产品名称：LKB1/STRADα/MO25α Protein, active, 125 µg
    产品型号：14-596M
    Active, recombinant full-length human LKB1 with an N-terminal 6His tag. Provided as a complex with GST-STRADα & GST-MO25α. For use in Kinase Assays.

    merck millipore,默克密理博,14-596M,LKB1/STRADα/MO25α Protein, active, 125 µg

  • 产品介绍
  • merck millipore,默克密理博,14-596M,LKB1/STRADα/MO25α Protein, active, 125 µg

    描述
    产品目录编号 14-596M
    品牌系列 Upstate
    商名
    • Upstate
    描述 LKB1/STRADα/MO25α Protein, active, 125 µg
    概述 Recombinant full-length human LKB1 with an N-terminal 6His tag. Provided as a complex with GST-STRADα and GST-MO25α.
    应用
    应用 Active, recombinant full-length human LKB1 with an N-terminal 6His tag. Provided as a complex with GST-STRADα & GST-MO25α. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in Sf21
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_000455.4
    Entrez基因汇总 This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
    基因符号
    • LKB1
    • STK11
    • PJS
    蛋白靶 LKB1
    纯化方法 GSH agarose followed by Ni2+/NTA agarose
    靶子系列 CAMK
    UniProt编号
    • Q15831
    UniProt汇总 FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
    COFACTOR: Magnesium or Manganese.
    SIZE: 433 amino acids; 48636 Da
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
    TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
    PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).
    DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
    SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of LKBtide.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 125 µg
    包装 Also available in 10 μg size (cat#14-596) and in bulk (cat# 14-596-K).

    merck millipore,默克密理博,14-596M,LKB1/STRADα/MO25α Protein, active, 125 µg

上一件merck millipore产品：merck millipore,默克密理博,MSHAS4510,MultiScreenHTS HA，0.45 µm，无色，无菌
下一件merck millipore产品：merck millipore,默克密理博,SF-2540,MAP4K2; Human, Cyanine 5 RNA Detection Probe,SmartFlare


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