merck millipore,默克密理博,04-458,Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,04-458,Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal
产品名称：Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal
产品型号：04-458
Detect phospho CD22 (Tyr822) using this Anti-phospho CD22 (Tyr822) Antibody, Rabbit validated for use in FC & WB.

merck millipore,默克密理博,04-458,Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-458,Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-458
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho CD22 (Tyr822) Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Detect phospho CD22 (Tyr822) using this Anti-phospho CD22 (Tyr822) Antibody, Rabbit validated for use in FC & WB.
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic phospho-peptide composed of residues surrounding Tyrosine 822 of human CD22.
宿主	Rabbit
特异性	Recognizes a region composed of residues surrounding Tyrosine 822 of human CD22.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001771.1
基因符号	BL-CAM CD22 SIGLEC-2 MGC130020 Leu-14 SIGLEC2 Siglec-2
修改	Phosphorylation
UniProt编号	P20273
UniProt汇总	FUNCTION: SwissProt: P20273 # Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. SIZE: 847 amino acids; 95348 Da SUBUNIT: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: B-lymphocytes. DOMAIN: SwissProt: P20273 Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. PTM: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. & Phosphorylated on tyrosine residues by LYN (By similarity). SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 6 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.