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描述 产品目录编号 14-594M 品牌系列 Upstate
商名 - Upstate
描述 VHR Protein, 250 µg 概述 N-terminal GST-tagged, recombinant VHR expressed in E. coli 应用 应用 N-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays. 主要应用 - Phosphatase Assay
生物信息 来源 recombinant human full-length VHR expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_004090.2
Entrez基因汇总 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. 基因符号 - VHR
- DUSP3
蛋白靶 VHR 纯化方法 Glutathione-agarose 靶子系列 Ser/Thr/Tyr phosphatase UniProt编号 - P51452
UniProt汇总 FUNCTION: SwissProt: P51452 # This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.
SIZE: 185 amino acids; 20478 Da
SIMILARITY: SwissProt: P51452 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 tyrosine-protein phosphatase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of DiFMUP 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-594) and in bulk (cat# 14-594-K).
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