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描述 产品目录编号 14-564 品牌系列 Upstate
商名 - Upstate
描述 SRPK1 Protein, active, 10 µg 概述 N-terminal GSTtagged recombinant human SRPK1 应用 应用 Active, N-terminal GST-tagged recombinant human SRPK1, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_003137.3
Entrez基因汇总 This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined. 基因符号 - SFRSK1
- SRPK1
蛋白靶 SRPK1 纯化方法 Glutathione-agarose 靶子系列 CMGC UniProt编号 - Q96SB4
UniProt汇总 FUNCTION: SwissProt: Q96SB4 # Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
COFACTOR: Magnesium.
SIZE: 826 amino acids; 92407 Da
SUBUNIT: Present in a seven component complex, the toposome, which separates entangled circular chromatin DNA during chromosome segregation. The extended N-terminal domain of isoform 1 binds to the nuclear scaffold-associated protein SAFB suggesting this isoform may phosphorylate splicing factors in close vicinity to the nuclear matrix.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Isoform 1 and isoform 2 are cytoplasmic and nuclear.TISSUE SPECIFICITY: Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2.
SIMILARITY: SwissProt: Q96SB4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of SRPK1tide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 10 µg
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