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描述 产品目录编号 14-524M 品牌系列 Upstate
商名 - Upstate
描述 MST2 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant human MST2 residues 2-end 应用 应用 Active, N-terminal His6-tagged recombinant human MST2 residues 2-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_006281.2
Entrez基因汇总 Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM] 基因符号 - KRS1
- STK3
- MST-2
- FLJ90748
- MST2
蛋白靶 MST2 纯化方法 Ni2+/NTA-agarose 靶子系列 STE UniProt编号 - Q13188
UniProt汇总 FUNCTION: SwissProt: Q13188 # Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates TITF1 (By similarity). Phosphorylates and activates LATS1 and LATS2.
COFACTOR: Magnesium.
SIZE: 491 amino acids; 56301 Da
SUBUNIT: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (By similarity). Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1, which leads to enzyme activation.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.
SIMILARITY: SwissProt: Q13188 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain. & Contains 1 SARAH domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-524) and in bulk (cat# 14-524-K).
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