merck millipore,默克密理博,09-853,Anti-eIF4A3 Antibody

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merck millipore,默克密理博,09-853,Anti-eIF4A3 Antibody
产品名称：Anti-eIF4A3 Antibody
产品型号：09-853
Anti-eIF4A3 Antibody is a rabbit polyclonal antibody for detection of eIF4A3 also known as ATP-dependent RNA helicase DDX48, Eukaryotic translation initiation factor 4A isoform 3 & has been validated More>>

merck millipore,默克密理博,09-853,Anti-eIF4A3 Antibody

产品介绍

merck millipore,默克密理博,09-853,Anti-eIF4A3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Serum	Polyclonal Antibody

描述
产品目录编号	09-853
描述	Anti-eIF4A3 Antibody
Alternate Names	hNMP 265 ATP-dependent RNA helicase DDX48 ATP-dependent RNA helicase eIF4A-3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 DEAD box protein 48 Eukaryotic initiation factor 4A-like NUK-34 Eukaryotic translation initiation factor 4A isoform 3 Nuclear matrix protein 265 eukaryotic translation initiation factor 4A, isoform 3
背景信息	Eukaryotic translation initiation factor 4A, isoform 3, also known as eIF4A3, is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. eIF4A3 is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.

产品信息
格式	Serum
控制	A431 cell lysate
演示	Rabbit polyclonal serum with 0.05% sodium azide.

应用
应用	Anti-eIF4A3 Antibody is a rabbit polyclonal antibody for detection of eIF4A3 also known as ATP-dependent RNA helicase DDX48, Eukaryotic translation initiation factor 4A isoform 3 & has been validated in WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic linear peptide corresponding to eIF4A3.
宿主	Rabbit
特异性	This antibody detects RNA-binding protein eIF4A3.
品种反应性	RatHumanMouse
Species Reactivity Note	Tested on human, mouse and rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_055555.1
Entrez基因汇总	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq].
基因符号	hNMP265 DDX48 EC 3.6.1.- EIF4AIII KIAA0111 MGC10862 NMP265 NUK-34 eIF4AIII
纯化方法	Unpurified
UniProt编号	P38919
UniProt汇总	FUCTION: Binds to spliced mRNAs and is involved in nonsense-mediated decay of mRNAs containing premature stop codons. SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, EIF4A3, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Part of the exon junction complex (EJC), a multisubunit complex which assembles near mRNA exon-exon junctions and which contains proteins involved in mRNA splicing, export, localization and nonsense-mediated decay. May interact with NOM1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. SEQUENCE SIMILARITIES: Belongs to the DEAD box helicase family. eIF4A subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

产品使用声明
质量保证	Evaluated by western blot on A431 cell lysate. Western Blot Analysis: 1:1000 dilution of this antibody detected eIF4A3 in A431 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

包装信息
数量	100 µL

merck millipore,默克密理博,09-853,Anti-eIF4A3 Antibody

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