merck millipore,默克密理愽
  • merck millipore,默克密理博,14-343,FKHR Protein, 100 µg

  • merck millipore,默克密理博,14-343,FKHR Protein, 100 µg

    产品名称：FKHR Protein, 100 µg
    产品型号：14-343
    N-terminal, Glutathione-Stransferase (GST) tagged, full-length fusion protein corresponding to human FKHR.

    merck millipore,默克密理博,14-343,FKHR Protein, 100 µg

  • 产品介绍
  • merck millipore,默克密理博,14-343,FKHR Protein, 100 µg

    描述
    产品目录编号 14-343
    品牌系列 Upstate
    商名
    • Upstate
    描述 FKHR Protein, 100 µg
    概述 N-terminal, Glutathione-Stransferase (GST) tagged, full-length fusion protein corresponding to human FKHR
    应用
    应用 N-terminal, Glutathione-Stransferase (GST) tagged, full-length fusion protein corresponding to human FKHR.
    主要应用
    • Western Blotting
    生物信息
    来源 Recombinant human expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002015.3
    Entrez基因汇总 This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
    基因符号
    • FOXO1A
    • FOXO1
    • FKHR
    • FKH1
    纯化方法 Glutathione-agarose
    UniProt编号
    • Q12778
    UniProt汇总 FUNCTION: SwissProt: Q12778 # Transcription factor.
    SIZE: 655 amino acids; 69662 Da
    SUBUNIT: Interacts with LRPPRC (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
    TISSUE SPECIFICITY: Ubiquitous.
    PTM: Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Thr-24, Ser-256 and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser- 329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.
    DISEASE: SwissProt: Q12778 # Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.
    SIMILARITY: SwissProt: Q12778 ## Contains 1 fork-head DNA-binding domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation by Akt1
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,14-343,FKHR Protein, 100 µg

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