merck millipore,默克密理愽
  • merck millipore,默克密理博,126870,Alsterpaullone - CAS 237430-03-4 - Calbiochem

  • merck millipore,默克密理博,126870,Alsterpaullone - CAS 237430-03-4 - Calbiochem

    产品名称：Alsterpaullone - CAS 237430-03-4 - Calbiochem
    产品型号：126870
    A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC₅₀ = 4 nM) and Cdk1/cyclin B (IC₅₀ = 35 nM).

    merck millipore,默克密理博,126870,Alsterpaullone - CAS 237430-03-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,126870,Alsterpaullone - CAS 237430-03-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₁N₃O₃237430-03-4
    描述
    概述 A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3β in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
    产品目录编号 126870
    品牌系列 Calbiochem®
    同义词 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
    参考
    参考 Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
    Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.
    产品信息
    CAS号 237430-03-4
    具有ATP竞争性 Y
    形式 Brown solid
    Hill配方 C₁₆H₁₁N₃O₃
    化学配方 C₁₆H₁₁N₃O₃
    Molar Mass 293.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 GSK-3β, Cdk1/cyclin B
    主靶IC50 4 nM, 35 nM, against GSK-3β, Cdk1/cyclin B, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,126870,Alsterpaullone - CAS 237430-03-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MAB858-3B-5,Anti-RSV Antibody, nucleoprotein, clone 130-12H


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