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merck millipore,默克密理博,557508,Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
产品名称：Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
产品型号：557508
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
merck millipore,默克密理博,557508,Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2 125313-65-7 描述 概述 A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM). 产品目录编号 557508 品牌系列 Calbiochem®
同义词 2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate 参考 参考 Zhang, C., et al. 1997. J. Immunol. 158, 4968.
Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.产品信息 CAS号 125313-65-7 具有ATP竞争性 Y 形式 Red to reddish-orange solid Hill配方 C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2 化学配方 C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2 Molar Mass 476.5 可逆 Y 结构配方图像 生物信息 主靶 rat brain PKC 主靶IC50 158 nM against rat brain PKC; 53 nM for PKCα, 195 nM for PKCβ, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε 纯度 ≥93% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.
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