merck millipore,默克密理愽
  • merck millipore,默克密理博,124020,Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

  • merck millipore,默克密理博,124020,Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

    产品名称：Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
    产品型号：124020
    The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,124020,Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124020,Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₅ClN₂O • HCl925681-41-0
    描述
    概述 A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
    产品目录编号 124020
    品牌系列 Calbiochem®
    同义词 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
    参考
    参考 Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
    Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
    产品信息
    CAS号 925681-41-0
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₀H₂₅ClN₂O • HCl
    化学配方 C₂₀H₂₅ClN₂O • HCl
    Molar Mass 381.4
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 Akt
    主靶IC50 <5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
    副靶 Rn cell lines (IC₅₀ = 2-5 µM)
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124020,Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-405,Lambda Protein Phosphatase, 20000 units
下一件merck millipore产品：merck millipore,默克密理博,580559,Paclitaxel, 6α-Hydroxy- - CAS 153212-75-0 - Calbiochem


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