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merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
产品名称:Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
产品型号:124012
The Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>
merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₃H₁₆N₆O₄ 35943-35-2 描述 概述 A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038). 产品目录编号 124012 品牌系列 Calbiochem®
同义词 NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2 参考 参考 Karst, A., et al. 2006. Cancer Res. 66, 9225.
Yang, L., et al. 2004. Cancer Res. 64, 4394.产品信息 CAS号 35943-35-2 具有ATP竞争性 N 形式 Solid Hill配方 C₁₃H₁₆N₆O₄ 化学配方 C₁₃H₁₆N₆O₄ Molar Mass 320.3 可逆 Y 结构配方图像 生物信息 主靶 Akt1, Akt 2, Akt3 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS RY8455000 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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