• merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
  • merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

    产品名称:Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
    产品型号:124012
    The Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>

    merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₆N₆O₄35943-35-2
    描述
    概述 A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
    产品目录编号 124012
    品牌系列 Calbiochem®
    同义词 NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
    参考
    参考 Karst, A., et al. 2006. Cancer Res. 66, 9225.
    Yang, L., et al. 2004. Cancer Res. 64, 4394.
    产品信息
    CAS号 35943-35-2
    具有ATP竞争性 N
    形式 Solid
    Hill配方 C₁₃H₁₆N₆O₄
    化学配方 C₁₃H₁₆N₆O₄
    Molar Mass 320.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Akt1, Akt 2, Akt3
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    GHS安全信息
    RTECS RY8455000
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124012,Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

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