- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
描述 产品目录编号 12-350 品牌系列 Upstate
商名 - Upstate
描述 GST 产品信息 演示 50mM Tris-HCl, pH 8.0, 5mM 2-mercaptoethanol 应用 应用 GST primarily used in Western Blotting. 主要应用 - Western Blotting
生物信息 Entrez基因编号 - NM_145740.2
Entrez基因汇总 Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. 基因符号 - GST-epsilon
- GSTA1
- GST2
- H-A
- GTH1
- GSTA1-1
- MGC131939
UniProt编号 - P08263
UniProt汇总 FUNCTION: SwissProt: P08263 # Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
SIZE: 222 amino acids; 25631 Da
SUBUNIT: Homodimer or heterodimer of GSTA1 and GSTA2.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Liver.
DOMAIN: SwissProt: P08263 The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
SIMILARITY: Belongs to the GST superfamily. Alpha family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -70°C 包装信息 数量 250 µg
上一件merck millipore产品：merck millipore,默克密理博,S7110,ApopTag Fluorescein In Situ Apoptosis Detection Kit
下一件merck millipore产品：merck millipore,默克密理博,ABC243,Anti-AKR1B10 Antibody
相关产品
merck millipore,默克密理博,MABE480,Anti-Bmi-1 Antibody, clone EPR3745(2), rabbit monoclonal
merck millipore,默克密理博,AP503P,Goat Anti-Mouse IgG γ chain Antibody, HRP conjugate, Species Adsorbed
merck millipore,默克密理博,MABF301,Anti-Interleukin-7/IL-7 Antibody, clone 7B1.1
merck millipore,默克密理博,MAB1671,Anti-Villin Antibody, clone ID2C3
merck millipore,默克密理博,S7110,ApopTag Fluorescein In Situ Apoptosis Detection Kit
merck millipore,默克密理博,ABC243,Anti-AKR1B10 Antibody
merck millipore,默克密理博,APT139,Caspase 9 Colorimetric Activity Assay Kit, LEHD
merck millipore,默克密理博,69866,pET-28c(+) DNA - Novagen
