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merck millipore,默克密理博,09-862,Anti-Histone H2A.Z Antibody
产品名称：Anti-Histone H2A.Z Antibody
产品型号：09-862
Use Anti-Histone H2A.Z Antibody (Sheep Polyclonal Antibody) validated in WB to detect Histone H2A.Z also known as H2A histone family member Z, H2AZ histone.
merck millipore,默克密理博,09-862,Anti-Histone H2A.Z Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, Ch, H, Zebrafish, Rb, R, Xn WB Sh Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-862 描述 Anti-Histone H2A.Z Antibody Alternate Names - H2AZ histone
- H2A histone family, member Z
- member Z
背景信息 H2A.Z, also known as H2AFZ, is a variant of histone H2A variant that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control. 产品信息 格式 Affinity Purified 控制 - HeLa cell lysate.
演示 Purified sheep polyclonal IgG in PBS, pH 7.4 containing with 1% BSA with 0.02% sodium azide. 应用 应用 Use Anti-Histone H2A.Z Antibody (Sheep Polyclonal Antibody) validated in WB to detect Histone H2A.Z also known as H2A histone family member Z, H2AZ histone. 主要应用 - Western Blotting
生物信息 免疫原品种 The immunogen was a linear peptide corresponding to C-terminal amino acids 113-127 of human Histone H2A.Z. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Sheep 特异性 This antibody recognizes Histone H2A.Z. 品种反应性 MouseChickenHumanZebrafishRabbitRatXenopus Species Reactivity Note Human. Predicted to cross-react with zebrafish, mouse, chicken, rat, rabbit, and Xenopus based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_036544
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene.
基因符号 - H2AFZ
- H2A.z
- H2A/z
- H2AZ
- MGC117173
UniProt编号 - P0C0S5
UniProt汇总 FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Ref.7
SUBUNIT STRUCTURE:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP By similarity.
SUBCELLULAR LOCATION:Nucleus.
PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis By similarity.
Not phosphorylated By similarity.
SIMILARITY: Belongs to the histone H2A family.
MOLECULAR WEIGHT: is 13413.4 Da from positions 2 - 128. Determined by ESI. Monoisotopic, not modified. Ref.8 Ref.10 Ref.11
产品使用声明 质量保证 Western Blot Analysis:
1:1,000 dilution of this lot detected Histone H2A.Z in 10 μg of HeLa cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 years at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. 包装信息 数量 100 µg
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