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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-158 品牌系列 Upstate
商名 - Upstate
描述 Anti-ALK7 Antibody 背景信息 ALK7 (ACVR1C activin A receptor, type IC; ACVRLK4) is a transmembrane type IC receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. The type I receptors (i.e. ALK7) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK7 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK7. 产品信息 格式 Affinity Purified 演示 Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-ALK7 Antibody is an antibody against ALK7 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide designed against the N-terminal region of human ALK7 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes ALK7 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_660302
Entrez基因汇总 ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM] 基因符号 - EC 2.7.11.30
- Activin receptor-like kinase 7
- Activin receptor type-1C precursor
- activin A receptor, type IC
- ACTR-IC
- ACVRLK7
- ALK-7
- ALK7
纯化方法 Affinity purified using immunogen UniProt编号 - Q8NER5
UniProt汇总 Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Size: 493 amino acids; 54871 Da
Subunit Structure: Binds the type 2 receptor protein ACVR2A
Subcellular Location: Membrane; Single-pass type I membrane protein.
Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.产品使用声明 质量保证 Routinely evaluated by western blot on either human or rat brain lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 200 µL
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