merck millipore,默克密理博,07-1708,Anti-FOXH1 Antibody

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merck millipore,默克密理博,07-1708,Anti-FOXH1 Antibody
产品名称：Anti-FOXH1 Antibody
产品型号：07-1708
Anti-FOXH1 Antibody is a Rabbit Polyclonal Antibody for detection of FOXH1 also known as Forkhead activin signal transducer, TGF-beta/activin signal transduce & has been validated in ICC.

merck millipore,默克密理博,07-1708,Anti-FOXH1 Antibody

产品介绍

merck millipore,默克密理博,07-1708,Anti-FOXH1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H, M	ICC	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1708
描述	Anti-FOXH1 Antibody
Alternate Names	forkhead box H1 Forkhead activin signal transducer 1 Forkhead activin signal transducer 2 TGF-beta/activin signal transducer forkhead activin signal transducer-1
背景信息	Forkhead box H1 (FOXH1) is a member of the HNF–3FKH family of transcriptional activators. FOXH1 is a winged helix with two loops on the C-terminal side expressed in all human tissue. FOXH1 is an embryonic transcription regulator and is an essential transcriptional co-activator that binds with SMAD2 to activate activin, and therefore induce the gooseciod (GSC) promoter. After FOXH1 binds to SMAD4, activin response element is activated and TGF-β is stimulated. FOXH1 also interacts with NKX2-5 to form an essential component of anterior heart field development. FOXH1 is associated with complex brain malfunctions due to incomplete cleavage of the prosencephalon, and in developmental delays resulting in facial abnormalities such as cyclopia and severe cleft lip or palate.

产品信息
格式	Affinity Purified
控制	NIH/3T3, HeLa, and A431 cells.
演示	Purified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

应用
应用	Anti-FOXH1 Antibody is a Rabbit Polyclonal Antibody for detection of FOXH1 also known as Forkhead activin signal transducer, TGF-beta/activin signal transduce & has been validated in ICC.
主要应用	Immunocytochemistry

生物信息
免疫原品种	Synthetic to peptide corresponding to FOXH1.
宿主	Rabbit
特异性	This antibody recognizes FOXH1.
品种反应性	HumanMouse
Species Reactivity Note	Human. Predicted to react with mouse based on sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_007989
基因符号	hFAST-1 FAST-1 FAST1 FAST2 Fast-1 Fast-2
纯化方法	Affinity Purfied
UniProt编号	O75593
UniProt汇总	FUNCTION:Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). Ref.1 SUBUNIT: Interacts with the MH2 domains of SMAD2 and SMAD3. Ref.1 SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. Ref.1 DOMAIN:The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex By similarity. Sequence similarities Contains 1 fork-head DNA-binding domain.

产品使用声明
质量保证	Evaluated by immunocytochemistry on NIH/3T3, HeLa, and A431 cells. Immunocytochemistry: 1:500 dilution of this antibody was used to detect FOXH1 in NIH/3T3, HeLa and A431 cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8ºC from date of receipt. To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 4-25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.

储存和货运信息

存储条件

Stable for 1 year at 2-8ºC from date of receipt.
To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 4-25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.

包装信息
数量	100 µg

merck millipore,默克密理博,07-1708,Anti-FOXH1 Antibody

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