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  • merck millipore,默克密理博,07-879,Anti-phospho-PKCγ (Thr655) Antibody

  • merck millipore,默克密理博,07-879,Anti-phospho-PKCγ (Thr655) Antibody

    产品名称：Anti-phospho-PKCγ (Thr655) Antibody
    产品型号：07-879
    Anti-phospho-PKCγ (Thr655) Antibody detects level of phospho-PKCγ (Thr655) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-879,Anti-phospho-PKCγ (Thr655) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-879,Anti-phospho-PKCγ (Thr655) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-879
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-PKCγ (Thr655) Antibody
    Alternate Names
    • PRKCG, PKC-gamma, PKCC, PKCG, SCA14, Protein Kinase C gamma
    • PRKCG
    • PKC-gamma
    • PKCC
    • PKCG
    • SCA14
    产品信息
    格式 Affinity Purified
    应用
    应用 Anti-phospho-PKCγ (Thr655) Antibody detects level of phospho-PKCγ (Thr655) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-PKCγ (Thr655).
    宿主 Rabbit
    特异性 Recognizes phosphor-PKCγ (Thr655). PKCα and PKCβII may cross react in high expressing cells.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Predicted to cross-react with mouse and rat based on complete sequence homology, but have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002739.3
    Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
    基因符号
    • PKCC
    • PRKCG
    • SCA14
    • MGC57564
    • PKC-gamma
    • PKCG
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P05129
    UniProt汇总 FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
    COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
    SIZE: 697 amino acids; 78448 Da
    SUBUNIT: Interacts with CDCP1.
    DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
    SIMILARITY: SwissProt: P05129 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-879,Anti-phospho-PKCγ (Thr655) Antibody

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