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merck millipore,默克密理博,07-594,Anti-Histone H2A.Z Antibody
产品名称：Anti-Histone H2A.Z Antibody
产品型号：07-594
Detect Histone H2A.Z also known as H2AZ histone with Anti-Histone H2A.Z Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
merck millipore,默克密理博,07-594,Anti-Histone H2A.Z Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-594 品牌系列 Upstate
商名 - Upstate
描述 Anti-Histone H2A.Z Antibody 产品信息 格式 Serum 演示 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Histone H2A.Z also known as H2AZ histone with Anti-Histone H2A.Z Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide containing the sequence SLIGKKGQQ, corres-ponding to the C-terminus of human histone H2A.Z 宿主 Rabbit 特异性 C-terminus of histone H2A.Z 同种型 IgG 品种反应性 Human Species Reactivity Note Broad species cross-reactivity is expected 抗体类型 Polyclonal Antibody Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. 基因符号 - H2A.z
- H2AFZ
- H2A/z
- H2A.Z
- MGC117173
- H2AZ
纯化方法 Serum UniProt编号 - P0C0S5
UniProt汇总 FUNCTION: SwissProt: P0C0S5 # Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
SIZE: 128 amino acids; 13553 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. & Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity). & Not phosphorylated (By similarity).
SIMILARITY: SwissProt: P0C0S5 ## Belongs to the histone H2A family.产品使用声明 质量保证 routinely evaluated by immunoblot on acid extracted proteins from HeLa cells and recombinant Histone H2A.Z (Catalog #14-597), no cross-reactivity with Histone H2A 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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