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merck millipore,默克密理博,07-586,Anti-phospho-STAT5A/B (Tyr694/699) Antibody
产品名称：Anti-phospho-STAT5A/B (Tyr694/699) Antibody
产品型号：07-586
Detect phospho-STAT5A/B (Tyr694/699) also known as signal transducer & activator of transcription 5A/B with Anti-phospho-STAT5A/B (Tyr694/699) Antibody (Rabbit Polyclonal Antibody), that has been demo More>>
merck millipore,默克密理博,07-586,Anti-phospho-STAT5A/B (Tyr694/699) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-586 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-STAT5A/B (Tyr694/699) Antibody 背景信息 The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation. 产品信息 格式 Affinity Purified 控制 - PDGF treated 3T3/NIH cells
演示 Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. 应用 应用 Detect phospho-STAT5A/B (Tyr694/699) also known as signal transducer & activator of transcription 5A/B with Anti-phospho-STAT5A/B (Tyr694/699) Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in DB & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine 694 of human STAT5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes phospho-STAT5A/B (Tyr694/699). 同种型 IgG 品种反应性 RatBovineHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_012448.3
Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. 基因符号 - STAT5
- STAT5B
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P51692
- P42229
UniProt汇总 FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SIZE: 787 amino acids; 89866 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
PTM: Tyrosine phosphorylated (By similarity).
DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.产品使用声明 质量保证 routinely evaluated with lysates from 3T3/NIH cells treated with PDGF 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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