- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-474 品牌系列 Upstate
商名 - Upstate
描述 Anti-p38γ/SAPK3 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect p38γ/SAPK3 using this Anti-p38γ/SAPK3 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-fusion protein corresponding to full-length human Anti-p38γ/SAPK3. 宿主 Rabbit 特异性 p38 gamma isoform/SAPK3 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002969
Entrez基因汇总 Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. 基因符号 - SAPK-3
- MAPK12
- ERK5
- P38GAMMA
- p38gamma
- ERK3
- ERK6
- ERK-6
- PRKM12
- SAPK3
纯化方法 Protein A chromatography UniProt编号 - P53778
UniProt汇总 FUNCTION: SwissProt: P53778 # Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
COFACTOR: Binds 2 magnesium ions.
SIZE: 367 amino acids; 41940 Da
SUBUNIT: Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5.
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Mitochondrial when associated with SH3BP5.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle and heart.
DOMAIN: SwissProt: P53778 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot in a RIPA lysate from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,MABF191,Anti-CSF1 Antibody, clone 2D10
下一件merck millipore产品：merck millipore,默克密理博,MABD34,Anti-Werner's syndrome helicase (WRN) Antibody, clone 20A11.1
merck millipore,默克密理博,PC420,Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb
merck millipore,默克密理博,ABE305-S,Anti-trimethyl Histone H3 (Lys36) Antibody, Trial Size
merck millipore,默克密理博,AB9672,Anti-Tau phospho Serine 214 Antibody
merck millipore,默克密理博,ABE213,Anti-monomethyl-Histone H3 (Lys79) Antibody
merck millipore,默克密理博,MABF191,Anti-CSF1 Antibody, clone 2D10
merck millipore,默克密理博,MABD34,Anti-Werner's syndrome helicase (WRN) Antibody, clone 20A11.1
merck millipore,默克密理博,MAB3678,Anti-Chloramphenicol Acetyltransferase Antibody, clone CAT-1
merck millipore,默克密理博,SNAPABTR,SNAP i.d. 2.0 Antibody Collection Tray
merck millipore,默克密理博,SF-2044,ETV4; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,475878,(+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem