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merck millipore,默克密理博,MABF191,Anti-CSF1 Antibody, clone 2D10
产品名称：Anti-CSF1 Antibody, clone 2D10
产品型号：MABF191
Anti-CSF1 Antibody, clone 2D10 is a highly specific mouse monoclonal antibody, that targets CSF1 & has been tested in western blotting & IHC.
merck millipore,默克密理博,MABF191,Anti-CSF1 Antibody, clone 2D10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MABF191 描述 Anti-CSF1 Antibody, clone 2D10 Alternate Names - CSF-1
- M-CSF
- MCSF
- Lanimostim
- Processed macrophage colony-stimulating factor 1
- Macrophage colony-stimulating factor 1
背景信息 Macrophage colony stimulating factor 1 (CSF1,CSF-1, M-CSF, MCSF) or Lanimostim is a cytokine that was first identified as a molecule that plays an important role in the survival, proliferation and differentiation of mononuclear cells such as phagocytes, macrophages and monocytes. Today however we know that CSF1 also serves several other functions in a variety of cell types. CSF1 is essential for normal bone development, osteoclast proliferation, and the resorption of bone. CSF1 is released by osteoclasts upon stimulation by parathyroid hormone. Additionally CSF1 impacts actin and cytoskeleton reorganization which effects cell adhesion and migration, and overstimulation of CSF1 in endothelial cells is linked to the development and progression of atherosclerosis. CSF1 is also highly expressed in the endometrial epithelium of the pregnant uterus and CSF1 is essential for normal embryonic implantation and placental development. CSF1 appears to play an important role in cancer as well; first CSF1 is an anti-tumor agent and increases macrophage expression of anti-tumor activity, but over expression of CSF1 in breast, bone, and several other forms of cancer appears to promote cell invasiveness, proliferation, and tumor survival. Finally, CSF1 as a secreted mature factor promotes the release of proinflammatory cytokines and serves as part of the innate immunity process for inflammation and infection. CSF1 is initially produced as a precursor that is membrane bound but processed and secreted upon stimulation. CSF1 is heavily glycosylated and found both in the ECM as well as surface membranes of cells. CSF1 receptor is found on numerous cell types including macrophages, endothelial cells, and osteoclasts. EMD-Millipore’s Anti-CSF1 mouse monoclonal antibody has been tested in western blot on recombinant protein and in paraffin embedded immunohistochemistry on human placental tissue sections. 产品信息 格式 Ascites 控制 - Human recombinant CSF1 protein
演示 Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
应用 应用 Anti-CSF1 Antibody, clone 2D10 is a highly specific mouse monoclonal antibody, that targets CSF1 & has been tested in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected CSF1 in human placenta tissue.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified recombinant fragment of human CSF1 expressed in E. Coli. 克隆 2D10 宿主 Mouse 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - CSF1
纯化方法 Unpurified UniProt编号 - P09603
产品使用声明 质量保证 Evaluated by Western Blotting in human recombinant CSF1 protein.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected human recombinant CSF1 protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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