- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-337 品牌系列 Upstate
商名 - Upstate
描述 Anti-SOS1 Antibody, CT 产品信息 格式 Purified 演示 Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. 应用 应用 Anti-SOS1 Antibody, CT is an antibody against SOS1 for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1) 宿主 Rabbit 特异性 SOS1 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005633
Entrez基因汇总 This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. 基因符号 - GINGF
- SOS1
- NS4
- SOS-1
- GF1
- HGF
- GGF1
纯化方法 Protein A chromatography UniProt编号 - Q07889
UniProt汇总 FUNCTION: SwissProt: Q07889 # Promotes the exchange of Ras-bound GDP by GTP.
SIZE: 1333 amino acids; 152464 Da
SUBUNIT: Interacts with GRB2. Interacts with phosphorylated LAT2.
TISSUE SPECIFICITY: Expressed in gingival tissues.
DISEASE: SwissProt: Q07889 # Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also designated GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. & Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common.
SIMILARITY: SwissProt: Q07889 ## Contains 1 DH (DBL-homology) domain. & Contains 1 N-terminal Ras-GEF domain. & Contains 1 PH domain. & Contains 1 Ras-GEF domain.产品使用声明 质量保证 routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,ABS583,Anti-AMH Antibody
下一件merck millipore产品：merck millipore,默克密理博,05-23-2101,Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem
相关产品
merck millipore,默克密理博,MABS21,Anti-PORCN Antibody, clone 15G12.1
merck millipore,默克密理博,14-411,Histone H3, Recombinant Xenopus laevis
merck millipore,默克密理博,AB9854,Anti-Growth Associated Protein 43 Antibody
merck millipore,默克密理博,HTS064RTA,Ready-to-Assay™ AT1 Angiotensin Receptor Frozen Cells
merck millipore,默克密理博,ABS583,Anti-AMH Antibody
merck millipore,默克密理博,116890,Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem
merck millipore,默克密理博,MABC72,Anti-TNF receptor-associated factor 1 (TRAF1) Antibody, clone 11B2.2
merck millipore,默克密理博,70087,Perfect DNA™ Markers, 0.1-12 kbp - Novagen
merck millipore,默克密理博,04-218,Anti-CREB Antibody, clone E306, rabbit monoclonal