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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-334 品牌系列 Upstate
商名 - Upstate
描述 Anti-PP2A Antibody, B' subunit 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-PP2A Antibody, B' subunit is validated for use in WB for the detection of PP2A. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 194-209 (ELFDSEDPRERDFLKT) of human B56 α isoform 宿主 Rabbit 特异性 PP2A B' subunit, all isoforms 同种型 IgG 品种反应性 RabbitHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004576
Entrez基因汇总 The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12. 基因符号 - PP2A-PR55B
- SCA12
- PR52B
- PR2APR55-BETA
- PR2AB55-BETA
- MGC24888
- PR55-BETA
- PPP2R2B
- PR2AB-BETA
- PP2A-B55beta
纯化方法 Protein A chromatography UniProt编号 - Q00005
UniProt汇总 FUNCTION: SwissProt: Q00005 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
SIZE: 443 amino acids; 51710 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
TISSUE SPECIFICITY: Brain.
DISEASE: SwissProt: Q00005 # Defects in PPP2R2B are the cause of spinocerebellar ataxia 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The molecular defect in SCA12 is the expansion of a CAG repeat in the 5'-UTR of the gene.
SIMILARITY: SwissProt: Q00005 ## Belongs to the phosphatase 2A regulatory subunit B family. & Contains 7 WD repeats.产品使用声明 质量保证 routinely evaluated by immunoblot on Jurkat cell lysates 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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