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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-293 品牌系列 Upstate
商名 - Upstate
描述 Anti-PICK1 Antibody 产品信息 格式 Affinity Purified 演示 50mM Glycine, pH 7.4, 0.2M Tris, 0.15M NaCl, 0.1mM EDTA, 5mg/ml BSA, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-PICK1 Antibody detects level of PICK1 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 His-tagged fusion protein corresponding to residues 317-416 of mouse PICK1 宿主 Rabbit 特异性 PICK1 同种型 IgG 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_012407
Entrez基因汇总 The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. 基因符号 - PRKCABP
- PICK1
- OTTHUMP00000028509
- MGC15204
- dJ1039K5
纯化方法 Immunoaffinity chromatography UniProt编号 - Q9NRD5
UniProt汇总 FUNCTION: SwissProt: Q9NRD5 # Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3-ACCN2 heteromeric cation channel.
SIZE: 415 amino acids; 46600 Da
SUBUNIT: Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with the channel proteins ACCN1 and ACCN2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate receptors GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A (By similarity). Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses.TISSUE SPECIFICITY: Ubiquitous.
PTM: Phosphorylated (By similarity).
SIMILARITY: SwissProt: Q9NRD5 ## Contains 1 AH domain. & Contains 1 PDZ (DHR) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from rat brain microsomal preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 200 µL
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