- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-1801 描述 Anti-G3BP1 Antibody Alternate Names - RasGAP-associated endoribonuclease G3BP
- ATP-dependent DNA helicase VIII
- GAP SH3 domain-binding protein 1
- GAP binding protein
- GTPase activating protein (SH3 domain) binding protein 1
- Ras-GTPase-activating protein SH3-domain-binding protein
背景信息 G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs. 产品信息 格式 Serum 控制 - HeLa cell lysates.
演示 Rabbit polyclonal serum with 0.05% NaN3. 应用 应用 Anti-G3BP1 Antibody detects level of G3BP1 & has been published & validated for use in WB & IP. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to C-terminal region of human G3BP1. 表位 C-terminus 宿主 Rabbit 特异性 This antibody detects G3BP1 at its C-terminal region. 品种反应性 RatMouseHuman Species Reactivity Note Human and Mouse. Not tested on other species. Rat expected to react as immunogen is 100% homologous. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005745
Entrez基因汇总 This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]
基因符号 - HDH-VIII
- EC 3.6.1
- G3BP
- G3BP-1
UniProt编号 - Q13884
UniProt汇总 FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
SUBUNIT STRUCTURE: Monomer and homodimer Probable. Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A By similarity. Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.
SUBCELLULAR LOCATION: Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic sideBy similarity. Cell junctionBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions By similarity.
TISSUE SPECIFICITY:Ubiquitous. Ref.1
DOMAIN: The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.
The SU domain binds calmodulin in a calcium-dependent manner By similarity.
PTM: Phosphorylated by CaM-kinase II By similarity.
SIMILARITY:Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 2 PH domains.
Contains 1 SU (syntrophin unique) domain.
产品使用声明 质量保证 Evaluated by western blot on HeLa cell lysates.
Western Blot Analysis:
1:1,000 dilution of this antibody was used to detect G3BP1 in HeLa, 293T and S10 cell lysates.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,MAB4310X,Anti-CD133 Antibody, clone 13A4, Alexa Fluor 488 conjugated
下一件merck millipore产品：merck millipore,默克密理博,CC1047,MMP-13, human, proform, his-tagged, E. coli recombinant
相关产品
merck millipore,默克密理博,MAB4146,Anti-BCRP Antibody, clone BXP-21
merck millipore,默克密理博,04-204,Anti-phospho-Cdc25C (Ser216) Antibody, clone E190, rabbit monoclonal
merck millipore,默克密理博,MAB8261-K,Anti-Influenza A, H1N1, clone 9B3.2
merck millipore,默克密理博,ABS381,Anti-GBP5 Antibody
merck millipore,默克密理博,MAB4310X,Anti-CD133 Antibody, clone 13A4, Alexa Fluor 488 conjugated
merck millipore,默克密理博,CC1047,MMP-13, human, proform, his-tagged, E. coli recombinant
merck millipore,默克密理博,MAB7776,Anti-Urokinase Antibody, NT fragment, clone 2G6.2
merck millipore,默克密理博,681300,von Willebrand Factor, Human Plasma
