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merck millipore,默克密理博,07-1580,Anti-KLF5 (Krüppel-like factor 5) Antibody
产品名称：Anti-KLF5 (Krüppel-like factor 5) Antibody
产品型号：07-1580
Use Anti-KLF5 (Krüppel-like factor 5) Antibody (Rabbit Polyclonal Antibody) validated in WB, ChIP, IHC to detect KLF5 also known as Krüppel-like factor 5.
merck millipore,默克密理博,07-1580,Anti-KLF5 (Krüppel-like factor 5) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M, R IHC, WB, ChIP Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1580 描述 Anti-KLF5 (Krüppel-like factor 5) Antibody Alternate Names - intestinal-enriched kruppel-like factor
- BTE-binding protein 2
- Basic transcription element-binding protein 2
- Colon krueppel-like factor
- GC box binding protein 2
- GC-box-binding protein 2
- Intestinal-enriched krueppel-like factor
- Kruppel-like factor 5
- Kruppel-like factor 5 (intestinal)
- Transcription factor BTEB2
- basic transcription element binding protein 2
- colon kruppel-like factor
背景信息 Krüppel-like factors (KLFs) zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. KLF5 protein is enriched in intestinal tissue. 产品信息 格式 Affinity Purified 控制 - PC3 lysate
演示 Affinity purified rabbit polyclonal serum with 0.05% NaN3 应用 应用 Use Anti-KLF5 (Krüppel-like factor 5) Antibody (Rabbit Polyclonal Antibody) validated in WB, ChIP, IHC to detect KLF5 also known as Krüppel-like factor 5. 主要应用 - Immunohistochemistry
- Western Blotting
- Chromatin Immunoprecipitation (ChIP)
应用说明 Chromatin Immunoprecipitation:
This antibody was demonstrated by an outside laboratory to be suitable for ChIP (2).
Immunohistochemistry:
This antibody was demonstrated by an outside laboratory to be suitable for immunohistochemistry using tumor tissue samples (3).
生物信息 免疫原品种 The immunogen was a KLH-conjugated synthetic peptide corresponding to amino acids 95-111 of mouse/rat KLF5. 宿主 Rabbit 特异性 This antibody recognizes human KLF5. A strong unidentified band at ~18 kDa is also detected in some cell lysates. 品种反应性 HumanMouseRat Species Reactivity Note Human and rat. Expected to react with mouse, as immunogen sequence is identical in mouse and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_033899.2
基因符号 - OTTHUMP00000018502
- CKLF
- BTEB2
- IKLF
纯化方法 Peptide affinity chromatography UniProt编号 - Q13887
UniProt汇总 FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed only in testis and placenta.
SEQUENCE SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
产品使用声明 质量保证 Western Blot Analysis: :
1:500 dilution of this lot detected KLF5 in 10 µg of PC3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
包装信息 数量 100 µL
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