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  • merck millipore,默克密理博,07-130,Anti-Ezrin Antibody

  • merck millipore,默克密理博,07-130,Anti-Ezrin Antibody

    产品名称：Anti-Ezrin Antibody
    产品型号：07-130
    This Anti-Ezrin Antibody is validated for use in WB, IH for the detection of Ezrin.

    merck millipore,默克密理博,07-130,Anti-Ezrin Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-130,Anti-Ezrin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-130
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Ezrin Antibody
    概述 Ezrin is also referred to as Villin-2 and Cytovillin
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 This Anti-Ezrin Antibody is validated for use in WB, IH for the detection of Ezrin.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 479-498 of human Ezrin (C-EPVSYHVQESLQDEGAEPTG)
    宿主 Rabbit
    特异性 Ezrin
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003379
    Entrez基因汇总 The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
    基因符号
    • DKFZp762H157
    • VIL2
    • Ezrin
    • CVL
    • Cytovillin
    • FLJ26216
    • CVIL
    • Villin-2
    • ezrin
    • MGC1584
    • cytovillin
    • p81
    纯化方法 Protein A chromatography
    UniProt编号
    • P15311
    UniProt汇总 FUNCTION: SwissProt: P15311 # Probably involved in connections of major cytoskeletal structures to the plasma membrane.
    SIZE: 586 amino acids; 69413 Da
    SUBUNIT: Interacts with MPP5 (By similarity). Interacts with SLC9A3R1 and PACE1.
    SUBCELLULAR LOCATION: Membrane. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
    TISSUE SPECIFICITY: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.DEVELOPMENTAL STAGE: Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.
    PTM: Phosphorylated by tyrosine-protein kinases.
    SIMILARITY: SwissProt: P15311 ## Contains 1 FERM domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from A431 cells or a mouse brain lysate
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-130,Anti-Ezrin Antibody

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