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品种反应性 主要应用 宿主 格式 抗体类型 R, M, H, Ca WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-1213 Replaces AB9072 描述 Anti-IP3 Receptor 1 Antibody Alternate Names - spinocerebellar ataxia 16
- IP3 receptor isoform 1
- Type 1 InsP3 receptor
- Type 1 inositol 1,4,5-trisphosphate receptor
- inositol 1,4,5-triphosphate receptor, type 1
- spinocerebellar ataxia 15
背景信息 IP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue. 产品信息 格式 Serum 控制 - C2C12 cell lysates
演示 Rabbit serum. Liquid 应用 应用 This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue. 生物信息 免疫原品种 Synthetic peptide from the N-terminal of human IP3 Receptor 1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody reacts with the 300 kDa IP3 Receptor 1 protein. 同种型 mixed IgGs 品种反应性 RatMouseHumanCanine Species Reactivity Note Proven to react with mouse and human. Expected to react with canine and rat based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - Q14643
基因符号 - SCA16
- INSP3R1
- IP3R
- IP3R1
- InsP3R1
- Insp3r1
- SCA15
纯化方法 Unpurified rabbit serum UniProt编号 - Q14643
UniProt汇总 FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
SUBUNIT STRUCTURE: Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 By similarity. Interacts with MRVI1 and CABP1 (via N-terminus).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed.
DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
PTM: Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels By similarity.
Phosphorylated on tyrosine residues.
INVOLVEMENT IN DISEASE: Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.
SEQUENCE SIMILARITIES: Belongs to the InsP3 receptor family.
Contains 5 MIR domains.产品使用声明 质量保证 Evaluated by Western Blot in C2C12 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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