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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-037 Replaces AB3821 品牌系列 Upstate
商名 - Upstate
描述 Anti-WAVE/Scar Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-WAVE/Scar Antibody is an antibody against WAVE/Scar for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion-protein corresponding to full length (residues 1-559) of human WAVE/Scar 宿主 Rabbit 特异性 WAVE/Scar 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003931
Entrez基因汇总 The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. 基因符号 - WAVE
- WASF1
- KIAA0269
- FLJ31482
- SCAR1
- WAVE1
纯化方法 Protein A chromatography UniProt编号 - Q92558
UniProt汇总 FUNCTION: SwissProt: Q92558 # Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.
SIZE: 559 amino acids; 61652 Da
SUBUNIT: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas.
TISSUE SPECIFICITY: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
DOMAIN:SwissProt: Q92558 Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
SIMILARITY: Contains 1 WH2 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 fibroblasts 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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