merck millipore,默克密理愽
  • merck millipore,默克密理博,06-697,Anti-FLIP Antibody, NT

  • merck millipore,默克密理博,06-697,Anti-FLIP Antibody, NT

    产品名称：Anti-FLIP Antibody, NT
    产品型号：06-697
    Anti-FLIP Antibody, NT detects level of FLIP & has been published & validated for use in IC, IH & WB.

    merck millipore,默克密理博,06-697,Anti-FLIP Antibody, NT

  • 产品介绍
  • merck millipore,默克密理博,06-697,Anti-FLIP Antibody, NT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ICC, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-697
    Replaces 04-1103
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-FLIP Antibody, NT
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-FLIP Antibody, NT detects level of FLIP & has been published & validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 1:300 on fresh frozen mouse mammary gland and tumor tissue. O/N @4°C
    Immunocytochemistry: 40,000 cells per well in standard 8 well chamber slides w/ O/N adherence. Fixation with 1:1 acetone:methanol, 10min @ -20°C. Permeablization in 1 xPBS w/ 1% Triton and 3mg/mL BSA. Primary antibody at 1:300 O/N @4°C
    生物信息
    免疫原品种 peptide corresponding to amino acids 2-17 of human FLIP (SAEVIHQVEEALDTDEC)
    宿主 Rabbit
    特异性 FLIP
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003879
    基因符号
    • FLAME-1
    • CFLAR
    • I-FLICE
    • CASP8AP1
    • Casper
    • Usurpin
    • FLIP
    • c-FLIPS
    • FLAME
    • CASH
    • c-FLIPL
    • CLARP
    • USURPIN
    • c-FLIPR
    • c-FLIP
    • MRIT
    纯化方法 Protein A chromatography
    UniProt编号
    • O15519
    UniProt汇总 FUNCTION: SwissProt: O15519 # Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
    SIZE: 480 amino acids; 55344 Da
    SUBUNIT: TNFRSF6 stimulation triggers recruitment to the death- inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
    TISSUE SPECIFICITY: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
    DOMAIN: SwissProt: O15519 The caspase domain lacks the active sites residues involved in catalysis.
    PTM: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
    SIMILARITY: Belongs to the peptidase C14 family. & Contains 2 DED (death effector) domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31, A431, HeLa, Jurkat or Raji cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-697,Anti-FLIP Antibody, NT

上一件merck millipore产品：merck millipore,默克密理博,07-2187,Anti-phospho LRP-6 Antibody (Thr1572)
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