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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-691 Replaces 04-1045 品牌系列 Upstate
商名 - Upstate
描述 Anti-Caspase 6 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Caspase 6 using this Anti-Caspase 6 Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide [CEENMTETDAFYKREMFD] corresponding to amino acids 16-32 of human Caspase 6 宿主 Rabbit 特异性 Caspase 6 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_032992
Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. 基因符号 - MCH2
- CASP6
- CASP-6
纯化方法 Protein A chromatography UniProt编号 - P55212
UniProt汇总 FUNCTION: SwissProt: P55212 # Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
SIZE: 293 amino acids; 33310 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
SIMILARITY: SwissProt: P55212 ## Belongs to the peptidase C14 family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,203392,(+)-Blebbistatin - CAS 1177356-70-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,FCCH100157,FlowCellect™ Human T Cell Caspase 3/7 Kit
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